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Investigation of cross-reactivities toward peanut and other nuts in relation to the age of allergic individuals

Project Code: T07014

20/04/2011

Saint Marys Hospital, Manchester
Pumphrey, R

This research project endeavoured to confirm or refute the earlier observation in a 1996 study on cross-reactivity to peanut and other nuts by carrying out both clinical studies and laboratory studies using a group of over 700 nut allergic individuals. The clinical study showed that the nut allergy did not start with one particular nut and then broaden but rather the first nut an individual reacts to reflects when ingestion occured. 66% of nut allergic individuals were allergic to only one nut and this was not dependent on the age of th individual, and of the remaining 33% there was no pattern in the progression from the first allergic nut to the second, suggesting allergy developed as a result of subsequent ingestion of the offending nut rather than a development of the allergy to the first nut. Cross-reactivity is not a natural progression of nut allergy as a patient ages but simply occurs to a proportion of nut allergic individuals.

This report covers the T07012, T07013, and T07014 projects. The project is also related to ZT0702: Allergy Database Service: The FSA Nut Allergy Clinical Database and Serum Bank, details of which can be found at: http://www.food.gov.uk/science/research/foodcomponentsresearch/allergyresearch/t07programme/t07projectlist/zt0702/

Final report

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