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Further development of a non-invasive biomarker to monitor gastro-intestinal health with special emphasis on reduction of risk of colon cancer (BIOMICS)
Project Code: N12013
University of Jena
Habermann, N ; Glei, M
This project investigated the impact of n-3 polyunsaturated fatty acids, in vitro, and fish-consumption, ex vivo, on putative surrogate end-points for colo-rectal cancer. The n-3 polyunsaturated fatty acids, (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid, (DHA) are abundant in oily fish and increased consumption may have beneficial effects in reducing risk of colo-rectal cancer.
Overall, the results from this project do not support the use of FW-associated assays as ex vivo biomarkers of colonic mucosa apoptosis, a putative surrogate end-point for colo-rectal cancer risk, and work is ongoing to validate their use as biomarkers of colonic mucosa gene expression. This project provides some experimental evidence for an effect of long chain n-3 PUFA on colon cell apoptosis, but this was not substantiated by experiments using samples from subjects consuming increased fish.
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