View Report Details

Further development of a non-invasive biomarker to monitor gastro-intestinal health with special emphasis on reduction of risk of colon cancer (BIOMICS)

Project Code: N12013

01/10/2010

University of Jena
Habermann, N ; Glei, M

This project investigated the impact of n-3 polyunsaturated fatty acids, in vitro, and fish-consumption, ex vivo, on putative surrogate end-points for colo-rectal cancer. The n-3 polyunsaturated fatty acids, (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid, (DHA) are abundant in oily fish and increased consumption may have beneficial effects in reducing risk of colo-rectal cancer.

Overall, the results from this project do not support the use of FW-associated assays as ex vivo biomarkers of colonic mucosa apoptosis, a putative surrogate end-point for colo-rectal cancer risk, and work is ongoing to validate their use as biomarkers of colonic mucosa gene expression. This project provides some experimental evidence for an effect of long chain n-3 PUFA on colon cell apoptosis, but this was not substantiated by experiments using samples from subjects consuming increased fish.

Final report

Some of the files on this site may be in a format that your computer can't read. However, you can download Readers and Viewers for the following document types below: