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Expression of polymorphism following alpha-tocopherol supplementation in healthy subjects

Project Code: N05032

01/10/2010

Kings College London
Kelly, F ;
Aston University
Griffiths, H

Large differences in the proteomes of plasma and nasal cells between individuals were observed at baseline, confirming that inter-individual differences in protein expression need to be taken into account before any future intervention studies involving supplements are carried out.
Nasal cells showed greater evidence of significant changes in protein supplementation following alpha-tocopherol supplementation compared to plasma cells. However, this study demonstrated that plasma cells were more amenable than nasal cell samples for protein mapping, due to their relatively higher abundance of proteins.
The findings provide useful new information regarding the way proteins that may be involved in the progression of atherosclerosis respond to alpha-tocopherol, as well as the benefits and limitations of the use of proteomic technologies.

Final report

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