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Randomised controlled trial to test the impact of increased consumption of wholegrain foods on cardiovascular disease risk (the WHOLEheart study)

Project Code: N02036;
Publication:

Brownlee IA, Moore C, Chatfield M, Richardson DP, Ashby P, Kuznesof SA, Jebb SA, Seal CJ. Markers of cardiovascular risk are not changed by increased whole-grain intake: the WHOLEheart study, a randomised, controlled dietary intervention. Br J Nutr. 2010 Jul;104(1):125-34.
Brownlee IA, Moore C, Chatfield M, Richardson DP, Ashby P, Kuznesof K, Jebb SA, Seal CJ. Using food frequency questionnaires or food diaries to investigate the impact of dietary intervention with prescribed amounts of wholegrain foods on estimated nutritional intake (the WHOLEheart study). Proceedings of the C&E Spring Meeting Whole Grain Global Summit (2009) www.aaccnet.org/cerealfoodsworld/pdfs/CFW-54-2-suppl.pdf

Brownlee IA, Moore C, Chatfield M, Richardson DP, Ashby P, Kuznesof K, Jebb SA, Seal CJ Whole grain consumption and dietary change in the 12-month period following participation in a randomised, controlled whole grain intervention (the WHOLEheart study). Proceedings of the C&E Spring Meeting Whole Grain Global Summit (2009). www.aaccnet.org/cerealfoodsworld/pdfs/CFW-54-2-suppl.pdf

Brownlee IA, Moore C, Chatfield M, Richardson DP, Ashby P, Kuznesof K, Jebb SA, Seal CJ. Impact of whole grain inclusion on biomarkers of cardiovascular disease risk in a large-scale randomised, controlled dietary intervention (the WHOLEheart study). Proceedings of the C&E Spring Meeting Whole Grain Global Summit (2009). www.aaccnet.org/cerealfoodsworld/pdfs/CFW-54-2-suppl.pdf

01/09/2010

University of Newcastle
Brownlee, I ; Seal, C; Kuznesof, S;
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge
Chatfield, M; Moore, C; Jebb, S

There is growing interest in the impact of different types of carbohydrate on long-term health. Epidemiological evidence suggests an inverse relationship between wholegrain consumption and the risk of a variety of non-communicable diseases including cardiovascular disease (CVD), type two diabetes and some cancers. Consumption of wholegrain foods in the UK is less than one portion per week, per person and well below the level which may confer health benefits. This study represents the first community-based randomised controlled trial of the impact of incremental increases in consumption of wholegrain foods on the risk of CVD. Importantly, biomarkers of wholegrain consumption and improved methods for assessing compliance will also be evaluated. This study will document the quantitative health impact in a community sample, together with qualitative information on the acceptability of wholegrain foods to provide a robust platform on which dietary recommendations can be based.

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