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Bioassay of BSE infectivity in further tissues by i.c. inocculation of cattle

Project Code: M03007

25/05/2010

Veterinary Laboratories Agency, New Haw
Hawkins, S

Bovine spongiform encephalopathy (BSE) is a priondisease of domestic cattle that was first recognised in Great Britain in 1986. This epidemic is thought to have originated by contamination of commercially processed feed with a scrapie-like agent.
A control strategy for BSE was constructed on assumptions about the development of disease (pathogenesis) based on natural scrapie of sheep and a scrapie origin of BSE. Control measures included the removal of prescribed offals from all slaughtered cattle to prevent contamination of human or animal food. However mouse bioassay failed to detect infectivity in tissues of the lymphoretiicular system of naturally-infected cattle questioning the hypothesis of a close similarity between the pathogenesis
of BSE and natural scrapie.

Final report

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