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Dose-response and mixture response of pesticides in vitro and in vivo
Project Code: T10008;
- Sams, C. & Jones, K. (2011) Human volunteer studies investigating the potential for toxicokinetic interactions between the pesticides deltamethrin; pirimicarb and chlorpyrifos-methyl following oral exposure at the acceptable daily intake. Toxicology Letters 200, 41-45
- Sams C, Patel K, Jones K. Biological monitoring for exposure to pirimicarb: method development and a human oral dosing study. Toxicol. Lett. 2009; doi:10.1016/j.toxlet.2009.01.018
- :Sams, C. & Jones, K. (2011) Biological monitoring for exposure to deltamethrin: a human oral dosing study and background levels in the UK general population. Toxicol Lett [Epub ahead of print, 25 April]
Health and Safety Lab (HSL)
Jones, K ; Johnson, P
The general population are exposed to mixtures of low levels of pesticide residues in the diet. It has been suggested that such mixtures may interact causing responses that would not be expected from exposure to the individual residues.
This project investigated the possible interaction of pesticide mixtures both in vitro and in human volunteers. The in vitro studies compared the effects of equipotent doses of pesticide mixtures on plasma and erythrocyte cholinesterase activity with the same potency dose for an individual pesticide. Human volunteer studies compared urine metabolites recovered and excretion half-lives for mixtures of pesticides, each at their Acceptable Daily Intakes, to those from individual pesticides at their Acceptable Daily Intake.
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