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Functional impact of polymorphisms of transport proteins upon pesticide delivery to the CNS
Project Code: T10015
University of Newcastle
Brown, C ; Williams, F; Mutch, E
There is concern about possible long-term health effects of exposure to low levels of pesticides in the environment and development of chronic ill health. The brain is protected from exposure by the ability of transport proteins in the blood brain barrier to limit penetration, and polymorphisms of transporters have been associated with an increased susceptibility to toxicity to the brain. We propose that genetic variability in sensitivity to exposure to pesticides may result from variability in the ability of transporters to limit pesticide penetration into the brain.
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