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Development and validation of an LC-MS-MS method for the determination of primary aromatic amines, and use of this for the assessment of migration models for foods with high packaging : food mass ratio
Project Code: A03060
Leatherhead Food International
Burch, R ;
Many primary aromatic amines (PAAs) are considered toxic and some are considered to be possible causes of cancer in humans. They may be found in multilayer films which are commonly used in food packaging, although proper preparation and curing of these films means that the amines should no longer be present. They may also be found in coloured food contact articles. Migration of PAAs is subject to legal limits, and items can be screened using a colorimetric test. However there are certain drawbacks to this test; the PAAs are not measured individually, but are compared with a single compound, aniline. This means that there may be some inaccuracies if different PAAs give a different response in the test to aniline. It is also preferable to be able to identify which particular PAAs are present, if at all, as some compounds are more harmful than others. One objective of this project, therefore, was to develop and validate a method to identify and quantify individual PAAs in a range of sample types.
A further objective was to test the migration of PAAs from a multilayer film when it was exposed to food simulants at different ratios. This is relevant because there are many uses for multilayer films, ranging from small sachets e.g. a single serve sachet for vinegar, which will have a high packaging : food ratio, to large pouches of soup or pasta sauce with a low packaging : food ratio.
The final objective was to test the developed method against migration of PAAs from coloured food contact materials and articles.
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