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Development of biomarkers based on cell cycling and proliferation to facilitate the risk assessment of food chemicals
Project Code: t01015
Leatherhead Food International
Lake, B ;
TNO BIBRA International Ltd.
A large number of food and environmental chemicals have been shown to produce tumours in experimental animals. Such chemicals can be broadly divided into genotoxic (substances that damage DNA) and non-genotoxic agents. While screening tests are available for DNA reactive (genotoxic) agents, non-genotoxic carcinogens are only normally identified by performing chronic rodent bioassay studies. The objective of this project is to develop biomarkers that are predictive of subsequent tumour formation by non-genotoxic chemicals in experimental animals. Such biomarkers could be employed in conjunction with biomarkers of exposure, to provide a better assessment of the hazard of food chemicals to humans.
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